Heiko braak biography template
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Researchers of the Human Brain Project (HBP) found that in Parkinson’s disease the volumes of certain brain regions decrease over time in a specific pattern that is associated with clinical symptoms and largely coincides with the pattern described in Braak’s famous staging theory. The new study published in Cortex provides a detailed description of the structural changes over a long period of time and with an unprecedented spatial detail.
Progressive degeneration of brain tissue in a Parkinson’s disease patient. Image adapted from Pieperhoff et al. 2022 (CC BY 4.0).
The team of researchers from Forschungszentrum Jülich, Heinrich-Heine-University Düsseldorf and Ernst-von-Bergmann Klinikum Potsdam analysed the changes of brain volumes in 37 Parkinson’s patients and 27 controls at up to 15 time points over up to 8.8 years using magnetic resonance imaging (MRI). Previous in vivo studies had either measured brain volumes in Parkinson’s patients only at fewer time points or over
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Heiko Braak
German anatomist
Heiko Braak | |
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Heiko Braak (left) in 2018 | |
| Born | (1937-06-16) 16 June 1937 (age 87) Kiel |
| Nationality | German |
| Education | University of Hamburg, University of Berlin, University of Kiel |
| Occupation(s) | Anatomist, Professor |
Heiko Braak (born 16 June 1937) is a German anatomist. Braak was born in Kiel, Schleswig-Holstein, and studied medicine at the universities of Hamburg, Berlin, and Kiel. He was Professor at the Institute of Clinical Neuroanatomy, Johann Wolfgang Goethe-University, Frankfurt am Main. Currently he is based at the 'Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Germany.[1]
Braak's early research focused on the morphology of the central nervous system of chondrichthyan fishes. In the holocephalan species Chimaera monstrosa (ratfish), he described, in the basal midline of the diencephalon, a previously unknown ependymall structure adjac
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Abstract
A relatively small number of especially susceptible nerve fängelse types within multiple neurotransmitter systems of the human central, peripheral, and enteric nervous systems (CNS, PNS, ENS) become involved in the degenerative process underlying sporadic Parkinson’s disease (sPD). The six-stage model we proposed for brain pathology related to sPD (Neurobiol Aging 2003) was a retrospective study of incidental and clinically diagnosed cases performed on unconventionally thick tissue sections (100 μm) from a large number of brain regions.The staging model emphasized what we perceived to be a sequential development of increasing degrees of Lewy pathology in anatomically interconnected regions together with the loss of aminergic projection neurons in, but not limited to, the locus coeruleus and substantia nigra. The same vikt was assigned to axonal and somatodendritic Lewy pathology, and the olfactory bulb was included for the first time in a sPD staging system. After years of